Poly(dimethylsiloxane): A Sustainable Human Skin Alternative for Transdermal Drug Delivery Prediction

Despite the advantages of transdermal drug delivery (TDD), which makes it a fast-growing area research in pharmaceutics, numerous challenges affect their development, limits exploring full potential this alternate route. In trying to address one these problems, is strongly believed that need for sustainable skin alternative paramount. Efforts made an attempt provide employing pharmaceutical analysis, by better utilising polymer membrane, namely poly(dimethylsiloxane), also known as PDMS are discussed. Several combined properties polymer, includes its relative stability comparison with human skin, make good candidate replacement skin. Modifications undertaken membrane (to create enhanced mimic permeation analysis) discussed and reviewed paper, including improved ability predict permeability both hydrophobic hydrophilic drugs. Optimisations related studying TDD limitations encountered documented reviewed. It hoped such developments field will ultimately lead researchers replacing optimised polymer-based alternatives delivery.